Vaccinia 1


Vaccinia 1 : Medicine. An infection, primarily local and limited to the site of inoculation, induced in man by inoculation with the vaccinia (cowpox) virus in order to confer resistance to smallpox (variola). On about the third day after vaccination, papules form at the site of inoculation which become transformed into umbilicated vesicles and later pustules; they then dry up, and the scab falls off on about the 21st day, leaving a pitted scar; in some cases there are more or less marked constitutional disturbances
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