Pharmacokinetics 1
Pharmacokinetics 1 : (a) This is the science which describes quantitatively the uptake of drugs by the body, their biotransformation, their distribution, metabolism, and elimination from the body. Both total amounts and tissue and organ concentrations are considered. "Toxicokinetics" is essentially the same term applied to xenobiotics other than drugs. [Duffus, 2000: Univ. Edinburgh Med School On-line Chemical Safety Glossary]; (b) The processes of absorption, distribution, metabolism and excretion of a drug or vaccine. [NIAID, 1997: HIV Vaccine Glossary]; (c) The study of the absorption, distribution, metabolism and excretion of a substance in any living system. [OECD, 1997: Occupational Exposure to Pesticides]; (d) The processes by which a chemical is handled, and transported within the body, including how it is absorbed into the body, how it is distributed in the body tissues, how it is transformed in the body to metabolites and other breakdown compounds, and how it is excreted. [OFA, 2000: Oxyfuels Glossary]; (e) The study of the time course of absorption, distribution, metabolism, and excretion of a foreign substance (e.g., a drug or pollutant) in an organism's body. [USEPA, 1992: GL for Exposure Assessment] [USEPA, 1992a: Dermal Exposure Assessment] [REAP, 1995: Residential Exposure Assessment Project]; (f) The field of study concerned with defining, through measurement or modeling, the absorption, distribution, metabolism, and excretion of drugs or chemicals in a biological system as a function of time. [USEPA, 1995: Benchmark Dose]; (g) The study of the way that drugs move through the body after they are swallowed or injected. [USEPA, 1997a: EPA Terms of Environment] [Cf. Toxicokinetics]
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