Physiologically Based Pharmacokinetic (PBPK) Model 1
Physiologically Based Pharmacokinetic (PBPK) Model 1 : (a) Physiologically based compartmental model used to characterize pharmacokinetic behavior of a chemical. Available data on blood flow rates, and metabolic and other processes which the chemical undergoes within each compartment are used to construct a mass_balance framework for the PBPK model. [IRIS, 1999: Glossary of IRIS Terms]; (b) For dermal exposure testing, use of models to estimate the dermal permeability constant and amounts absorbed by the best_fit method based on blood concentration_time profile data or by monitoring the appearance and amounts of metabolites in postexposure urine samples or by measuring the concentration of parent compound in the expired air. [USEPA, 1992a: Dermal Exposure Assessment]
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