Safety Factor, Factor of Safety
Safety Factor, Factor of Safety :
A value used in the extrapolation from experimental animal studies to the population (in general). For PRC assessments, this represents a value applied to the NOAEL to derive an ADI or ARfD. The value depends on the nature of the effect, the dose-response relationship, and the quality of the toxicological information available. The use of such a factor accounts for possible differences in susceptibility between the animal species tested and humans, and for variation between different individuals in the population. The terms 'safety margin', 'uncertainty factor', and 'assessment factor' are also sometimes used as alternatives to 'safety factor'. The PRC uses the term 'safety factor'
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