Target organ effects indicate which bodily organs are most likely to be affected by exposure to a substance. Additional Info: The classes of target organ effects are described fully in Appendix A of 29 CFR 1910.1200, an Appendix to the Hazard Communication Standard (HCS) that defines health effects. While MSDS's and OSHA refer specifically to organs that can be damaged by a substance, the medical community also refers to organs targeted by diseases or other conditions. For example, the medical literature discusses target organ damage to the brain, heart and kidneys in the context of hypertension (high blood pressure). These target organ effects can manifest themselves even before hypertension is diagnosed or progresses from the pre-hypertensive state. Other diseases/conditions target other organs, of course. MSDS Relevance: MSDS's are required to report know target organ effects (if any). When working with chemicals that have target organ effects it is critical to prevent exposure. This is especially true if you have a pre-existing condition, disease or injury to that particular organ. OSHA requires that all hazardous materials be labeled with appropriate hazard warnings, including target organ effects (if known). Some official interpretations include: (1) Definitions of target organ and hazards of chemicals under the Hazard Communication Standard. (2) The HCS's requirement for target organ effects on labels for shipped containers of hazardous chemicals. (3) Clarification of the terms "appropriate hazard warning" and "mandatory". Read the MSDS to determine the most effective personal protective equipment (PPE) for dealing with the chemical and be certain to minimize release of the chemical in the first place. See also: Health Hazard, RTECS, Toxic