Target Organs/Site
Target Organs/Site : Those parts of the body that particular chemicals always affect. For example, lead affects the central nervous system (brain and spinal cord) but is stored in the bones where it accumulates with further exposures. Therefore, the target organs for lead are both the central nervous system and the bones. Other target organs for different toxic substances include the heart, lungs, kidneys and liver. The target site refers to the location(s) at which adverse effects occur. Toxicity may be relatively specific to an organ system or even cell type therein but generally toxicity will occur at several sites. Patterns of physiologic response, (syndromes), may give clues as to toxic etiologies. An example would be lead which at very low dosages causes subtle neuropsychiatric effects which with ongoing exposure become permanent and which as dose increases will affect bone marrow hemoglobin production and renal function
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