Toxicity Data
Toxicity Data : (a) Quantal Data: Specifies the number of animals affected as a function of dose rate (e.g., mg/kg/day) for a single type of effect. The number of animals with tumors or that die from a chemical exposure is an example. Quantal data are often reported as an incidence (percent response) and, thus, can be used to construct a dose-response curve. (b) Continuous Data: Represents the change in some measured value of a biological indicator (e.g., organ weights, triglyceride levels in the liver, and serum enzyme measurements) as a function of dose rate. Continuous data can be used to construct a dose-effect curve. (c) Graded Data: Specifies the form of severity of adverse effects as a function of dose rate without reference to the number of animals affected or to a continuous measure of one parameter. Graded data often are presented as categories (liver necrosis, lung lesions) or as judgments of severity. Fatty infiltration of the liver, single-cell liver necrosis, and liver necrosis are examples of sequence of severity judgments. Graded data can be used to construct a doseseverity curve
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