Toxicological Effects
Toxicological Effects : (a) Additive: Situation in which the combined effect of two chemicals is equal to the sum of the effect of each agent given alone (e.g., 2+3=5). (b) Synergistic: Situation in which the combined effect of two chemicals is much greater than the sum of the effect of each agent given alone (e.g., 2+3=20). (c) Potentiation: Situation in which one substance does not have a toxic effect, but when it is added to another chemical, it makes the latter much more toxic (e.g., 0+3=10). (d) Antagonism: Situation in which two chemicals given together interfere with each other's actions or one interferes with the action of the other chemical (e.g., 4+6=8, 4+0=1, 4+4=0)
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