Accumulation 5
Accumulation 5 : Medicine. Repeated doses of a chemical may result in its concentration in an organism, organ or tissue increasing progressively and the toxic effects may become more marked with successive doses. Factors involved in accumulation include selective binding of the chemical to tissue molecules, concentration of fat soluble chemicals in body fat, absent or slow metabolism, and slow excretion. Accumulation is a mass balance effect where input exceeds output. [Duffus, 2000: Univ. Edinburgh Med School On-line Chemical Safety Glossary]
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