Uncertainty Factor (UF) 3
Uncertainty Factor (UF) 3 : One of several, generally 10-fold, factors used in operationally deriving a standard or a reference dose from experimental data. UFs are intended to account for - (a) The variation in sensitivity among the members of the human population. (b) The uncertainty in extrapolating animal data to the case of humans. (c) The uncertainty in extrapolating from data obtained in a study involving less-than-lifetime exposure. (d) The uncertainty in using lowest-observed adverse effect level data rather than NOAEL data. (e) The inability of any single study to address adequately all possible adverse outcomes in man
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