Veno-Occlusive Disease-VOD
Veno-Occlusive Disease-VOD : The other major cause of hepatic venous outflow obstruction is veno-occlusive disease; it differs from Budd-Chiari syndrome in that it is the smaller intrahepatic venules within the liver that are primarily involved usually in a non-thrombotic manner. There is usually a defined exposure to a toxic agent or physical injury. In some parts of the world naturally occurring toxins (pyrrolizidine alkaloids - Jamaican bush tea) remains a significant cause of hepatic disease, particularly in children. Presently in the United States bone marrow transplantation is the most frequent setting for the development of VOD. This is related to the radiation and chemotherapeutic agents used in these patients. Renal transplant patients receiving immunosuppression agents are also at risk for VOD
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