ALT 4
ALT 4 : Formerly SGPT - Alanine aminotransferase - a protein which, when found in the blood in elevated quantities, generally indicates liver damage. It is found mainly in liver cells and therefore has greater specificity for liver disease, but it offers little other advantage. In most liver diseases, the AST increase is less than that of ALT (AST/ALT ratio is less than 1), except in alcohol-related liver injury where the ratio?is usually more than (2) Many exceptions limit the practicality of the ratio. However, a ratio of more than 3 with an inordinate increase in GGT (more than 2 times the alkaline phosphatase) is highly suggestive. Increase of serum alanine aminotransferase is seen in any condition involving necrosis of hepatocytes, myocardial cells, erythrocytes, or skeletal muscle cells
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