Biomarkers Fall into Three Principal Categories
Biomarkers Fall into Three Principal Categories : Exposure, susceptibility and effect. Exposure assessments have traditionally depended almost exclusively on measurements or model predictions of concentrations of chemical pollutants in relevant environmental media such as air, water, food and soil. An example of a biomarker of exposure is a measurement of a substance or its metabolite and provides an indication of degree of exposure. A biomarker of effect is a measurable biochemical, physiologic or other alteration within an organism that, depending on magnitude can indicate potential or established disease (DNA adducts, specific enzyme activity etc).A biomarker of susceptibility is an indicator of an inherent or acquired variation in an organism's ability to tolerate a specific substance. Susceptibility may vary due to combinations of environmental characteristics, genetic predisposition, age, gender, diet, lifestyle factors, comorbidity and other factors. Optimally a biomarker should be an indicator of both dose and effect
No records Found