Cell Biology. The committment of a cell to a particular path of differentiation, even though there may be no morphological features that reveal this determination. Generally irreversible, but in the case of imaginal discs of Drosophila that are maintained by serial passage, transdetermination may occur. This entry appears with permission from the Dictionary of Cell and Molecular Biology. Determination may refer to:; Cell fate determination; Co-determination; Coefficient of determination; Determination (God Forbid album), 2001; Determination (Tommy Emmanuel album), 1992; Expert determination; Hidden surface determination; Orbit determination; Presidential Determination; Sex-determination; Self-determination; Van Slyke determination; Zeisel determination; Zerewitinoff determination; Determination, a concept in dialectics. An OSH glossary used in safety and health at work which is, adopted by ILO {102}. The term definition has been obtained from the secondary source