Reference Dose (RfD) 4


Reference Dose (RfD) 4 : An estimate of a daily oral exposure to the human population that is likely to be without appreciable risk of deleterious effects during a lifetime. A RfD can be derived from a NOAEL, LOAEL or benchmark dose, with uncertainty factors applied to reflect limitations of the data used. RfDs are generally used by the US EPA in their non-cancer health assessments. In this context, a RfD is not itself an action level, nor does it establish an acceptable daily dose. Their primary use is to evaluate increments of exposure from specific sources above background when background exposures are low and insignificant
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