Storage Depot


Storage Depot : A storage depot is a site or tissue which sequesters a toxin without a deleterious effect. Examples include sequestration of lead into the calcium hydroxyapatite matrix of bone cortex and DDT or other organochlorines entry and storage in fatty tissues. Such storage depots allow for decreased bioavailabity of a sequestered toxin, biologic persistence with chronic low level exposure, (equilibrium between the storage depot and blood stream), decreased excretion and biologic persistence
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