Clearance 12
Clearance 12 :
(1) Volume of blood or plasma or mass of an organ effectively cleared of a substance by elimination (metabolism and excretion) in a given time interval: clearance is expressed in units of volume or mass per unit of time. Total clearance for a component is the sum of the clearances of each eliminating organ or tissue for that component. (2) In pulmonary toxicology, clearance refers specifically to removal of any inhaled substance which deposits on the lining surface of the lung: lung clearance is expressed in volume or mass of lung cleared per unit time. (3) In renal toxicology, clearance refers to the quantification of the removal of a substance by the kidneys by the processes of filtration and secretion: clearance is calculated by relating the rate of renal excretion to the plasma concentration. Related term: elimination
