Surrender and devotion to the regular use of a medicinal or pleasurable substance for the sake of relief, comfort, stimulation, or exhilaration which it affords; often with craving when the drug is absent. See: Dependence
International Union of Pure and Applied Chemistry IUPAC, Glossary for Chemists of Terms Used in Toxicology, Prepared for publication by J.H. Duffus, NC., USA 1993. http://www.inchem.org/documents/harmproj/harmproj/ harmproj1.pdf & http://old.iupac.org/reports/1993/6509duffus/c.htm l, (IUPAC/ Tox - Amer) {107}