Cytochrome P-450
Cytochrome P-450 :
Haemoproteins which form the major part of the enzymes concerned with the mono-oxygenation of many endogenous and exogenous substrates. The term includes a large number of iso-enzymes which are coded for by a superfamily of genes. Endogenous substrates of these enzymes include cholesterol, steroid hormones and the eicosenoids; the exogenous substrates are xenobiotics. Strictly, the cytochrome P450 family are not cytochromes but are haem-thiolate proteins. Syn: Mixed-Function Oxidase. Related term: cytochrome P-420, cytochrome P-448, endoplasmic reticulum, microsome, mono-oxygenase, phase 1 reactions,xenobiotics
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