Dose-Response Curve 1
Dose-Response Curve 1 : (a) A mathematical relationship between the dose administered or received and the incidence of adverse health effects in the exposed population; toxicity values are derived from this relationship. [AIHA, 2000: Risk Assessment Principles for the Industrial Hygienist]; (b) This is a graph to show the relation between the dose of a drug or xenobiotic and the degree of response it produces, as measured by the percentage of the exposed population showing a defined, often quantal, effect. If the effect determined is death, such a curve may be used to estimate an LD50 value. [Duffus, 2000: Univ. Edinburgh Med School On-line Chemical Safety Glossary]; (c) A graphical representation of the quantitative relationship between potential, applied or internal dose of an agent, and a specific biological response to that agent. [REAP, 1995: Residential Exposure Assessment Project]; (d) A graphical representation of the quantitative relationship between administered, applied, or internal dose of a chemical or agent, and a specific biological response to that chemical or agent. [USEPA, 1992: GL for Exposure Assessment]; (e) A quantitative relationship between administered, applied, or internal dose and probability of occurrence of a health effect or effects. Results are usually expressed in units of incidence per unit dose. [USEPA, 1992a: Dermal Exposure Assessment]; (f) Graphical representation of the relationship between the dose of a stressor and the biological response thereto. [USEPA, 1997a: EPA Terms of Environment]
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