Medicine. The death and decay of body tissue, often occurring in a limb, caused by insufficient blood supply and usually following injury or disease. Additional Info: Gangrene is usually noticed by the black color of the affected tissue (resulting from formation of iron sulfide from decomposed hemoglobin) and a putrid (foul) odor. A type of gangrene called gas gangrene is caused by anaerobic bacteria, organisms that do not require oxygen to live. In fact, oxygen is a poison to these kinds of bacteria and one effective treatment for gas gangrene is to place the victim in a hyperbaric oxygen chamber, one that contains 100% oxygen at a pressure 2 to 3 times normal atmospheric pressure. This helps oxygen permeate the affected tissue and kills the bacteria. Treatment usually includes antibiotics as well as surgery to remove the affected tissue, sometimes including amputation. Left untreated, gangrene can be fatal. Most of the risk factors for gangrene are not occupational and are beyond the scope of this article. Examples of these include diabetes, smoking, poor circulation etc. If you suffer any minor bodily injury or trauma, monitor your injury for signs of infection (such as swelling, redness, etc). and seek medical attention if necessary. See: The links under Further Reading for more information. MSDS Relevance: It is rare to See: This term on an MSDS. It usually appears in reference to injuries such as a high pressure injection of material under the skin or exposure to certain biological agents. Gangrene can also develop in cases of frostbite. If you work with cryogenic (very cold) materials, the MSDS should recommend proper protection (gloves etc). to avoid frostbite and caution workers to monitor any injuries for signs of infection. See also: Air, Dermal, Edema, Inflammation, Urticaria