Limit of Detection ( LOD) 1
Limit of Detection ( LOD) 1 :
Chemistry and Chemical Disasters. The lowest concentration of an analyte that the bioanalytical procedure can reliably differentiate from background noise. http: //www.fda.gov/downloads/Drugs/Guidances/ucm070107.pdf Smallest amount of analyte which can be distinguished from background. A good estimate for unbiased analyses, with media blanks not distinguishable from background, is three times the standard error of the calibration graph for low concentrations, divided by the slope (instrument reading per unit mass or per unit concentration of analyte). Source: NIOSH Manual of Analytical Methods. NIOSH Manual of Analytical Methods (NMAM®), 4th ed. DHHS (NIOSH) Publication 94-113 (August, 1994)
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