Antagonism 1
Antagonism 1 : (a) When the adverse effect or risk from two or more chemicals interacting with each other is less than what it would be if each chemical was acting separately. [ED, 2000: Environmental Scorecard Glossary]; (b) Opposite of synergism. The situation in which the combined effect of two or more factors is smaller than the solitary effect of any one of the factors. In bioassay, the term may be used to refer to the situation when a specified response is produced by exposure to either of two factors but not by exposure to both together. [Last, 1983: A Dictionary of Epidemiology]; (c) Interference or inhibition of the effect of one chemical by the action of another. [USDOE, 2000: RAIS Glossary]; (d) Interference or inhibition of the effect of one chemical by the action of another. [USEPA, 1997a: EPA Terms of Environment] [Cf. Synergism]
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