Acceptable Daily Intake (ADI) 01
Acceptable Daily Intake (ADI) 01 : (a) The highest daily amount of a substance that may be consumed over a lifetime without adverse effects. [CARB, 2000: Glossary of Air Pollution Terms]; (b) This is an estimate of the amount of a substance in food that can be ingested daily over a lifetime by humans without appreciable health risk. The concept of the ADI has been developed principally by WHO and FAO and is relevant to chemicals such as additives to foodstuffs, residues of pesticides and veterinary drugs in foods. ADIS are derived from laboratory toxicity data, and from human experiences of such chemicals when this is available, and incorporate a safety factor. The ADI is thus an estimate of the amount of a substance in food that can be ingested over a lifetime by humans without appreciable health risk (for contaminants in food and drinking water, Tolerable Intakes - daily or weekly - are used). See: Tolerable Daily Intake. [Duffus, 2000: Univ. Edinburgh Med School On-line Chemical Safety Glossary]; (c) The ADI of a chemical is the estimate of the amount of a substance in food and/or drinking water, expressed on a bodyweight basis, that can be ingested daily over a lifetime without appreciable health risk to the consumer on the basis of all the known facts at the time of the evaluation. It is usually expressed in milligrams of the chemical per kilogram of body weight. [FAO/WHO, 1997: Food Consumption & Exp. Assessment of Chemicals]; (d) The amount of a chemical a person can be exposed to on a daily basis over an extended period of time (usually a lifetime) without suffering deleterious effects. [IRIS, 1999: Glossary of IRIS Terms]; (e) Same as "Reference Dose". Estimate of largest amount of exposure to an agent on a daily basis not expected to result in adverse effects. [REAP, 1995: Residential Exposure Assessment Project]; (f) An estimate of the daily exposure dose that is likely to be without deleterious effect even if continued exposure occurs over a lifetime. [USDOE, 2000: RAIS Glossary]
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