Any substance that can induce heritable changes (mutations) of the genotype in a cell as a consequence of alterations or loss of genes or chromosomes (or parts thereof)
International Union of Pure and Applied Chemistry IUPAC, Glossary for Chemists of Terms Used in Toxicology, Prepared for publication by J.H. Duffus, NC., USA 1993. http://www.inchem.org/documents/harmproj/harmproj/ harmproj1.pdf & http://old.iupac.org/reports/1993/6509duffus/c.htm l, (IUPAC/ Tox - Amer) {107}