Medicine. (1) Mass death of areas of tissue or bone surrounded by healthy areas.(2) Morphological changes that follow cell death, characterized most frequently by nuclear changes.
International Union of Pure and Applied Chemistry IUPAC, Glossary for Chemists of Terms Used in Toxicology, Prepared for publication by J.H. Duffus, NC., USA 1993. http://www.inchem.org/documents/harmproj/harmproj/ harmproj1.pdf & http://old.iupac.org/reports/1993/6509duffus/c.htm l, (IUPAC/ Tox - Amer) {107}